發(fā)布者：抗性基因網(wǎng) 時間：2023-06-12 瀏覽量：426
摘要
? ? ? 現(xiàn)在人們普遍擔(dān)心廣泛的抗生素耐藥性，越來越多的證據(jù)表明，腸道微生物群在提供抗生素耐藥性方面至關(guān)重要。蜜蜂是一種重要的傳粉昆蟲；蜜蜂腸道中抗生素抗性基因的發(fā)生不僅對自身健康，而且對公眾和動物健康造成潛在風(fēng)險，因為其潛在的傳播作用，因此越來越受到公眾的關(guān)注。最近的分析結(jié)果表明，蜜蜂的腸道是抗生素抗性基因的庫，這可能是由于抗生素在養(yǎng)蜂中的應(yīng)用歷史和來自高度污染環(huán)境的水平基因轉(zhuǎn)移。這些抗生素抗性基因在蜜蜂腸道中積累，并可能轉(zhuǎn)移到病原體中，甚至有可能在授粉、照料、社交等過程中傳播。新獲得的抗性特征可能會導(dǎo)致細菌適應(yīng)度降低，同時促進適應(yīng)性進化。這篇綜述概述了目前關(guān)于蜜蜂腸道耐藥性的知識，并強調(diào)了其在抗生素耐藥性傳播中的作用。
Abstract
There is now general concern about widespread antibiotic resistance, and growing evidence indicates that gut microbiota is critical in providing antibiotic resistance. Honeybee is an important pollinator; the incidence of antibiotic resistance genes in honeybee gut causes potential risks to not only its own health but also to public and animal health, for its potential disseminator role, thus receiving more attention from the public. Recent analysis results reveal that the gut of honeybee serves as a reservoir of antibiotic resistance genes, probably due to antibiotics application history in beekeeping and horizontal gene transfer from the highly polluted environment. These antibiotic resistance genes accumulate in the honeybee gut and could be transferred to the pathogen, even having the potential to spread during pollination, tending, social interactions, etc. Newly acquired resistance traits may cause fitness reduction in bacteria whereas facilitating adaptive evolution as well. This review outlines the current knowledge about the resistome in honeybee gut and emphasizes its role in antibiotic resistance dissemination.
https://onlinelibrary.wiley.com/doi/abs/10.1111/1749-4877.12714