發(fā)布者：抗性基因網(wǎng) 時(shí)間：2023-06-12 瀏覽量：392
摘要
? ? ? 抗微生物耐藥性是對(duì)人類、動(dòng)物和環(huán)境健康的全球性威脅。在養(yǎng)豬生產(chǎn)中，抗菌劑和氧化鋅等重金屬通常用于治療和預(yù)防疾病。然而，抗菌劑和重金屬對(duì)豬耐藥性組成的影響以及影響這種耐藥性的因素尚不完全清楚。確定不同樣本類型中是否存在抗微生物耐藥性基因的技術(shù)進(jìn)步，使人們能夠更全面地了解耐藥性組及其影響其組成的因素。這篇綜述的目的是更好地了解抗菌藥物和重金屬的使用對(duì)養(yǎng)豬場抗菌藥物耐藥性的發(fā)展和傳播的影響。此外，本綜述旨在確定可能影響豬耐藥性的其他因素。使用PubMed（NCBI）、Scopus（Elsevier）和Web of Science（Clarivate Analytics）數(shù)據(jù)庫的系統(tǒng)方法，鑒定了使用高通量測序或定量PCR方法來檢測抗微生物耐藥性與抗微生物和重金屬使用之間聯(lián)系的相關(guān)文獻(xiàn)?？偣舶l(fā)現(xiàn)了247份獨(dú)特的記錄，28份出版物被確定為有資格納入本次審查?；谶@些，有明確的證據(jù)表明，使用抗菌藥物和重金屬與豬的抗菌藥物耐藥性呈正相關(guān)。此外，還報(bào)道了賦予抗微生物耐藥性的基因與可移動(dòng)遺傳元件、微生物組和病毒組的關(guān)聯(lián)，這些關(guān)聯(lián)進(jìn)一步受到宿主、環(huán)境或治療本身的影響。
Abstract
Antimicrobial resistance is a global threat to human, animal, and environmental health. In pig production, antimicrobials and heavy metals such as zinc oxide are commonly used for treatment and prevention of disease. Nevertheless, the effects of antimicrobials and heavy metals on the porcine resistome composition and the factors influencing this resistance profile are not fully understood. Advances in technologies to determine the presence of antimicrobial resistance genes in diverse sample types have enabled a more complete understanding of the resistome and the factors which influence its composition. The aim of this review is to provide a greater understanding of the influence of antimicrobial and heavy metal usage on the development and transmission of antimicrobial resistance on pig farms. Furthermore, this review aims to identify additional factors that can affect the porcine resistome. Relevant literature that used high-throughput sequencing or quantitative PCR methods to examine links between antimicrobial resistance and antimicrobial and heavy metal use was identified using a systematic approach with PubMed (NCBI), Scopus (Elsevier), and Web of Science (Clarivate Analytics) databases. In total, 247 unique records were found and 28 publications were identified as eligible for inclusion in this review. Based on these, there is clear evidence that antimicrobial and heavy metal use are positively linked with antimicrobial resistance in pigs. Moreover, associations of genes conferring antimicrobial resistance with mobile genetic elements, the microbiome, and the virome were reported, which were further influenced by the host, the environment, or the treatment itself.
https://link.springer.com/article/10.1186/s13567-023-01143-3