發(fā)布者：抗性基因網(wǎng) 時(shí)間：2023-06-12 瀏覽量：401
摘要
出身背景
嚴(yán)重急性呼吸系統(tǒng)綜合征冠狀病毒2型感染對胃腸道及其常駐微生物組有顯著影響。據(jù)報(bào)道，嚴(yán)重感染病例和健康個(gè)體之間存在明顯差異，包括共生類群的損失。我們的目的是了解包括功能改變在內(nèi)的微生物群改變是否是新冠肺炎嚴(yán)重病例或常見影響所特有的。我們使用高分辨率系統(tǒng)多組學(xué)分析來分析無癥狀至中度新冠肺炎患者與對照組相比的腸道微生物群。
后果
我們發(fā)現(xiàn)新冠肺炎病毒毒力因子和抗菌藥物耐藥基因的總體豐度和表達(dá)顯著增加。重要的是，這些基因由來自酸性氨基球菌科和丹毒梭狀芽孢桿菌科等家族的共生分類群編碼和表達(dá)，我們發(fā)現(xiàn)這些基因在COVID-19陽性個(gè)體中富集。我們還發(fā)現(xiàn)，與健康對照組相比，新冠肺炎陽性個(gè)體中β-皰疹病毒和輪狀病毒C基因的表達(dá)增加。
結(jié)論
我們的分析發(fā)現(xiàn)，新冠肺炎患者腸道微生物組的感染能力發(fā)生了改變，并有所增加。
Abstract
Background
Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection and healthy individuals have been reported, including the loss of commensal taxa. We aimed to understand if microbiome alterations including functional shifts are unique to severe cases or a common effect of COVID-19. We used high-resolution systematic multi-omic analyses to profile the gut microbiome in asymptomatic-to-moderate COVID-19 individuals compared to a control group.
Results
We found a striking increase in the overall abundance and expression of both virulence factors and antimicrobial resistance genes in COVID-19. Importantly, these genes are encoded and expressed by commensal taxa from families such as Acidaminococcaceae and Erysipelatoclostridiaceae, which we found to be enriched in COVID-19-positive individuals. We also found an enrichment in the expression of a betaherpesvirus and rotavirus C genes in COVID-19-positive individuals compared to healthy controls.
Conclusions
Our analyses identified an altered and increased infective competence of the gut microbiome in COVID-19 patients.
https://link.springer.com/article/10.1186/s40168-023-01472-7